The objective of the present study was to formulate and evaluate of curcumin liquisolid tablets to enhance the dissolution profile of poorly water soluble drug curcumin. Liquisolid formulations were prepared by direct compression method using loading factor (Lf) and retention value (R-value) calculation to get acceptable flowable and compressible powder form. Different curcumin liquisolid formulations (LSF 1 to LSF 3) were prepared by using different non-volatile solvents like propylene glycol, tween-80 and span-80 and their dissolution profile compared with curcumin direct compression tablet. The curcumin liquisolid tablets were within the acceptable limits and drug release rate of all liquisolid tablets were higher than the direct compression tablet. LSF 2 (88.52%) liquisolid formulation shows higher drug release than LSF 1 (85.57%) and LSF 3 (82.62%) formulations. All the preformulation parameters were evaluated such as solubility, melting point, bulk density, tapped density, Hausner’s ratio, angle of repose and Carr’s index. FTIR analysis confirmed no interaction between drug and excipients. Liquisolid formulations showed improved in in-vitro dissolution behaviour of curcumin than direct compression tablet. From this study, it was concluded that liquisolid method is a promising alternative for enhancement of dissolution property of water insoluble drugs.
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